BLISOVI FE 1/20 - AN OVERVIEW

Sulfates are the most important circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The primary oxidative metabolite is two-hydroxy ethinyl estradiol, formed through the CYP3A4 isoform of cytochrome P450. Part of the primary-go metabolism of ethinyl estradiol is considered to arise in gastrointestinal mucosa. Ethinyl